Causal inference for long-term survival in randomised trials with treatment switching: Should re-censoring be applied when estimating counterfactual survival times?
نویسندگان
چکیده
منابع مشابه
rpsftm: An R Package for Rank Preserving Structural Failure Time Models.
Treatment switching in a randomised controlled trial occurs when participants change from their randomised treatment to the other trial treatment during the study. Failure to account for treatment switching in the analysis (i.e. by performing a standard intention-to-treat analysis) can lead to biased estimates of treatment efficacy. The rank preserving structural failure time model (RPSFTM) is ...
متن کاملA general implementation of TMLE for longitudinal data applied to causal inference in survival analysis.
In many randomized controlled trials the outcome of interest is a time to event, and one measures on each subject baseline covariates and time-dependent covariates until the subject either drops-out, the time to event is observed, or the end of study is reached. The goal of such a study is to assess the causal effect of the treatment on the survival curve. We present a targeted maximum likeliho...
متن کاملAssessing methods for dealing with treatment switching in clinical trials: A follow-up simulation study.
When patients randomised to the control group of a randomised controlled trial are allowed to switch onto the experimental treatment, intention-to-treat analyses of the treatment effect are confounded because the separation of randomised groups is lost. Previous research has investigated statistical methods that aim to estimate the treatment effect that would have been observed had this treatme...
متن کاملAdjusting for treatment changes in epilepsy: causal analysis of randomised controlled trial survival outcomes in the presence of departure from randomised treatment
Treatment changes are typical in epilepsy because of the chronic nature of the disease and common problems with treatment, most typically inadequate seizure control and unacceptable adverse effects. Randomised trials in epilepsy often adopt a pragmatic approach to treatment changes, in order to cater for patient needs and mirror the real-life experience of patients. Trial patients may experienc...
متن کاملInference for the effect of treatment on survival probability in randomized trials with noncompliance and administrative censoring.
In many clinical studies with a survival outcome, administrative censoring occurs when follow-up ends at a prespecified date and many subjects are still alive. An additional complication in some trials is that there is noncompliance with the assigned treatment. For this setting, we study the estimation of the causal effect of treatment on survival probability up to a given time point among thos...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2018